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Gpx1tm1Ysh
Targeted Allele Detail
Nomenclature
Symbol: Gpx1tm1Ysh
Name: glutathione peroxidase 1; targeted mutation 1, Ye-Shih Ho
MGI ID: MGI:2158814
Synonyms: Gpx1-, GpX-1 KO, GPX1 KO, GSHPx-1-deficient
Gene: Gpx1  Location: Chr9:108216279-108217541 bp, + strand  Genetic Position: Chr9, 59.24 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41169
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a neomycin resistance cassette disrupted exon 2 of the gene. Northern blots of total RNA isolated from brain, heart, kidney, liver, and lung of homozygous mutant mice showed no detectable transcript of the targeted gene when probed with an a gene-specific cDNA probe. (J:41169)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gpx1 Mutation:  24 strains or lines available
References
Original:  J:41169 Ho YS, et al., Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem. 1997 Jun 27;272(26):16644-51
All:  68 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory