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Fkbp1atm1Zuk
Targeted Allele Detail
Nomenclature
Symbol: Fkbp1atm1Zuk
Name: FK506 binding protein 1a; targeted mutation 1, Martin M Matzuk
MGI ID: MGI:2158807
Synonyms: FKBP12m1
Gene: Fkbp1a  Location: Chr2:151542483-151561692 bp, + strand  Genetic Position: Chr2, 74.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45536
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn Hprt minigene replaced a genomic fragment containing exons 3 and 4, which encode domains required for protein activity. (J:45536)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 21 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fkbp1a Mutation:  11 strains or lines available
References
Original:  J:45536 Shou W, et al., Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Nature. 1998 Jan 29;391(6666):489-92
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory