About   Help   FAQ
Nos2tm1Mrl
Targeted Allele Detail
Summary
Symbol: Nos2tm1Mrl
Name: nitric oxide synthase 2, inducible; targeted mutation 1, Merck Research Laboratory
MGI ID: MGI:2158791
Synonyms: iNOS-, iNOS KO, NOS2-, Nos2tm1Ntn
Gene: Nos2  Location: Chr11:78811613-78851052 bp, + strand  Genetic Position: Chr11, 46.74 cM
Alliance: Nos2tm1Mrl page
Renal tubular apoptosis, regeneration, glomerulosclerosis and glomerular thrombus formation in Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25511
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing 585 bp of the promoter and exons 1-4. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that no detectable transcript was produced from this allele. However, a transcript has been reported from sequence downstream from exon 4. (J:25511, J:53925)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 21 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Nos2 Mutation:  66 strains or lines available
References
Original:  J:25511 MacMicking JD, et al., Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase [published erratum appears in Cell 1995 Jun 30;81(7):following 1170]. Cell. 1995 May 19;81(4):641-50
All:  154 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory