Nos2tm1Mrl
Targeted Allele Detail
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Symbol: |
Nos2tm1Mrl |
Name: |
nitric oxide synthase 2, inducible; targeted mutation 1, Merck Research Laboratory |
MGI ID: |
MGI:2158791 |
Synonyms: |
iNOS-, iNOS KO, NOS2-, Nos2tm1Ntn |
Gene: |
Nos2 Location: Chr11:78811613-78851052 bp, + strand Genetic Position: Chr11, 46.74 cM
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Alliance: |
Nos2tm1Mrl page
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Renal tubular apoptosis, regeneration, glomerulosclerosis and glomerular thrombus formation in Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:25511
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Parent Cell Line: |
AB2.1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing 585 bp of the promoter and exons 1-4. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that no detectable transcript was produced from this allele. However, a transcript has been reported from sequence downstream from exon 4.
(J:25511, J:53925)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:25511 MacMicking JD, et al., Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase [published erratum appears in Cell 1995 Jun 30;81(7):following 1170]. Cell. 1995 May 19;81(4):641-50 |
All: |
154 reference(s) |
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