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Targeted Allele Detail
Symbol: Nos2tm1Liew
Name: nitric oxide synthase 2, inducible; targeted mutation 1, Foo Y Liew
MGI ID: MGI:2158787
Synonyms: iNOS-
Gene: Nos2  Location: Chr11:78920787-78960254 bp, + strand  Genetic Position: Chr11, 46.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:25755
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Other
Mutation detailsA genomic rearrangement of the gene occurred, but the expected deletion of exons 1-5 did not occur by homologous recombination. An aberrant 4.5 kb mRNA was expressed from this allele, and western blot experiments on proteins derived from macrophages of homozygous mice confirmed that no detectable protein was made. (J:25755)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nos2 Mutation:  32 strains or lines available
Original:  J:25755 Wei XQ, et al., Altered immune responses in mice lacking inducible nitric oxide synthase. Nature. 1995 Jun 1;375(6530):408-11
All:  10 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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