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F3tm1Jld
Targeted Allele Detail
Nomenclature
Symbol: F3tm1Jld
Name: coagulation factor III; targeted mutation 1, Jay L Degen
MGI ID: MGI:2158778
Synonyms: TF-
Gene: F3  Location: Chr3:121723537-121735048 bp, + strand  Genetic Position: Chr3, 52.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33831
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn Hprt minigene replaced a 6.0 kb genomic fragment containing the proximal promoter region, the transcription start site, exons 1, 2 and part of 3. Reduced clotting activity in brain and lung microsome sections was shown in in heterozygous mice. (J:33831)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F3 Mutation:  11 strains or lines available
References
Original:  J:33831 Bugge TH, et al., Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6258-63
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory