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Targeted Allele Detail
Symbol: Il6tm1Poli
Name: interleukin 6; targeted mutation 1, Valeria Poli
MGI ID: MGI:2158764
Synonyms: IL-6-
Gene: Il6  Location: Chr5:30013114-30019975 bp, + strand  Genetic Position: Chr5, 15.7 cM
Il6tm1Poli/Il6tm1Poli mice exhibit increased susceptibility to Candida albicans infection

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:17249
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exons 1, 2 and 3 was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from LPS-induced splenocytes of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA assays confirmed that no detectable protein was produced in homozygous mice. (J:17249, J:47064)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il6 Mutation:  26 strains or lines available
Original:  J:17249 Poli V, et al., Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 1994 Mar 1;13(5):1189-96
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory