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Plgtm1Dco
Targeted Allele Detail
Nomenclature
Symbol: Plgtm1Dco
Name: plasminogen; targeted mutation 1, Desire Collen
MGI ID: MGI:2158761
Synonyms: plasminogen-, Plg-
Gene: Plg  Location: Chr17:12378609-12419384 bp, + strand  Genetic Position: Chr17, 8.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30174
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plg Mutation:  4 strains or lines available
Notes
Homozygous mutant mice survive embryonic development, but after birth show retarded growth and reduced fertility and survival. Impaired thrombolysis and fibrin deposition are observed. The symptoms resemble those following loss of both tissue and urokinase plasminogen activation (J:30174). Treatment of null mutant mice with exogenous plasminogen restores thrombolysis (J:34531). Ligneous conjunctivitis (OMIM 217090) has also been ascribed to PLG mutations (J:48307).

References
Original:  J:30174 Ploplis VA, et al., Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation. 1995 Nov 1;92(9):2585-93
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory