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Targeted Allele Detail
Symbol: Plgtm1Dco
Name: plasminogen; targeted mutation 1, Desire Collen
MGI ID: MGI:2158761
Synonyms: plasminogen-, Plg-
Gene: Plg  Location: Chr17:12378609-12419384 bp, + strand  Genetic Position: Chr17, 8.5 cM
Germline Transmission:  Earliest citation of germline transmission: J:30174
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exons 15-17 which encodes part of the catalytic domain. Northern blot analysis on RNA derived from liver of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA assays on plasma derived from homozygous mice confirmed that no active protein was detectable. (J:30174)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plg Mutation:  3 strains or lines available
Homozygous mutant mice survive embryonic development, but after birth show retarded growth and reduced fertility and survival. Impaired thrombolysis and fibrin deposition are observed. The symptoms resemble those following loss of both tissue and urokinase plasminogen activation (J:30174). Treatment of null mutant mice with exogenous plasminogen restores thrombolysis (J:34531). Ligneous conjunctivitis (OMIM 217090) has also been ascribed to PLG mutations (J:48307).
Original:  J:30174 Ploplis VA, et al., Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation. 1995 Nov 1;92(9):2585-93
All:  50 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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