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Casp3tm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Casp3tm1Flv
Name: caspase 3; targeted mutation 1, Richard Flavell
MGI ID: MGI:2158753
Synonyms: Casp3-, caspase-3-, CPP32-
Gene: Casp3  Location: Chr8:47070326-47092724 bp, + strand  Genetic Position: Chr8, 26.39 cM
Skeletal defects in Casp3tm1Flv/Casp3tm1Flv and Casp3tm1Flv/Casp3+ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36821
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing sequences encoding a conserved motif was replaced with a neomycin selection cassette. RT-PCR analysis on samples derived from brain and liver of homozygous mice demonstrated that no detectable transcript is produced from this allele. Western blot analysis on samples derived from thymocytes of homozygous mice confirmed that no detectable protein was produced. (J:36821)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 21 assay results
In Structures Affected by this Mutation: 27 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Casp3 Mutation:  26 strains or lines available
References
Original:  J:36821 Kuida K, et al., Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 1996 Nov 28;384(6607):368-72
All:  79 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory