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Targeted Allele Detail
Symbol: Casp1tm1Flv
Name: caspase 1; targeted mutation 1, Richard Flavell
MGI ID: MGI:2158744
Synonyms: Casp1-, caspase-1-, ICE-
Gene: Casp1  Location: Chr9:5298517-5307281 bp, + strand  Genetic Position: Chr9, 2.46 cM
Alliance: Casp1tm1Flv page
Germline Transmission:  Earliest citation of germline transmission: J:24258
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing part of exon 6 and exon 7 was replaced with a neomycin selection cassette. RT-PCR analysis on samples derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:24258)
View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Casp1tm1Flv
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Casp1 Mutation:  30 strains or lines available
The ES cells used to generate this allele contain the linked Casp4del truncated allele that fails to produce a functional Casp4. Phenotypes associated with this allele may be affected by the presence of the Caspdel allele. J:193522
Original:  J:24258 Kuida K, et al., Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science. 1995 Mar 31;267(5206):2000-3
All:  427 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory