Casp1^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Casp1^tm1Flv
• Name: caspase 1; targeted mutation 1, Richard Flavell
• MGI ID: MGI:2158744
• Synonyms: Casp1^-, caspase-1-, ICE-
• Gene: Casp1 Location: Chr9:5298517-5307281 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Casp1^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24258
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing part of exon 6 and exon 7 was replaced with a neomycin selection cassette. RT-PCR analysis on samples derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:24258)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Casp1^tm1Flv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Casp1 Mutation: 41 strains or lines available

Notes

The ES cells used to generate this allele contain the linked Casp4^del truncated allele that fails to produce a functional Casp4. Phenotypes associated with this allele may be affected by the presence of the Casp^del allele. J:193522

References

• Original: J:24258 Kuida K, et al., Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science. 1995 Mar 31;267(5206):2000-3
• All: 444 reference(s)