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Targeted Allele Detail
Symbol: Ciitatm1Jpyt
Name: class II transactivator; targeted mutation 1, Jenny P Y Ting
MGI ID: MGI:2158705
Synonyms: CIITA -, CIITA G-
Gene: Ciita  Location: Chr16:10480059-10528418 bp, + strand  Genetic Position: Chr16, 5.65 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:57100
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.0 kb genomic fragment containing sequences encoding the GTP-binding domain was replaced with a neomycin selection cassette. RT-PCR analysis on samples derived from spleen, thymus and lymph nodes from homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:57100)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ciita Mutation:  8 strains or lines available
Original:  J:57100 Itoh-Lindstrom Y, et al., Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain. J Immunol. 1999 Sep 1;163(5):2425-31
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory