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Targeted Allele Detail
Symbol: Rarbtm1Vgi
Name: retinoic acid receptor, beta; targeted mutation 1, Vincent Giguere
MGI ID: MGI:2158691
Synonyms: RARbeta-
Gene: Rarb  Location: Chr14:5650540-6038924 bp, + strand  Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
Germline Transmission:  Earliest citation of germline transmission: J:29061
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing sequences encoding the first zinc finger motif was replaced with a neomycin selection cassette. This region encodes an essential portion of the protein common to all encoded isoforms. Northern blot analysis on RNA derived from E13.5 homozygous embryos demonstrated that no detectable transcript is produced from this allele. (J:29061)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 64 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rarb Mutation:  27 strains or lines available
Original:  J:29061 Luo J, et al., Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev. 1995 Sep;53(1):61-71
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory