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Rarbtm1Vgi
Targeted Allele Detail
Nomenclature
Symbol: Rarbtm1Vgi
Name: retinoic acid receptor, beta; targeted mutation 1, Vincent Giguere
MGI ID: MGI:2158691
Synonyms: RARbeta-
Gene: Rarb  Location: Chr14:16430842-16575472 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29061
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing sequences encoding the first zinc finger motif was replaced with a neomycin selection cassette. This region encodes an essential portion of the protein common to all encoded isoforms. Northern blot analysis on RNA derived from E13.5 homozygous embryos demonstrated that no detectable transcript is produced from this allele. (J:29061)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 36 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rarb Mutation:  15 strains or lines available
References
Original:  J:29061 Luo J, et al., Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev. 1995 Sep;53(1):61-71
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory