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Irs2tm1Mfw
Targeted Allele Detail
Nomenclature
Symbol: Irs2tm1Mfw
Name: insulin receptor substrate 2; targeted mutation 1, Morris F White
MGI ID: MGI:2158686
Synonyms: Irs2-
Gene: Irs2  Location: Chr8:10984681-11008458 bp, - strand  Genetic Position: Chr8, 5.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46134
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector containing a PGK-neomycin cassette replaced the entire gene. Lack of protein was demonstrated in liver and muscle extracts by Western analysis in homozygous mutant animals. (J:46134)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irs2 Mutation:  14 strains or lines available
References
Original:  J:46134 Withers DJ, et al., Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 1998 Feb 26;391(6670):900-4
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/05/2018
MGI 6.12
The Jackson Laboratory