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Blmtm3Brd
Targeted Allele Detail
Nomenclature
Symbol: Blmtm3Brd
Name: Bloom syndrome, RecQ helicase-like; targeted mutation 3, Allan Bradley
MGI ID: MGI:2158670
Synonyms: Blm-, Blmm3
Gene: Blm  Location: Chr7:80454993-80535119 bp, - strand  Genetic Position: Chr7, 45.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66261
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThis allele is a derivative of Blmtm2Brd. Three copies of a targeting vector that contained loxP sites inserted into the gene. Cre mediated recombination led to a deletion of the copies. This allele retains an extra copy of exon 3. However, western blot analysis on protein extracts of testes demonstrated that no detectable protein was produced from this allele. (J:66261)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Blm Mutation:  29 strains or lines available
References
Original:  J:66261 Luo G, et al., Cancer predisposition caused by elevated mitotic recombination in bloom mice. Nat Genet. 2000 Dec;26(4):424-9
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory