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Blmtm3Brd
Targeted Allele Detail
Summary
Symbol: Blmtm3Brd
Name: Bloom syndrome, RecQ like helicase; targeted mutation 3, Allan Bradley
MGI ID: MGI:2158670
Synonyms: Blm-, Blmm3
Gene: Blm  Location: Chr7:80104741-80184896 bp, - strand  Genetic Position: Chr7, 45.65 cM
Alliance: Blmtm3Brd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66261
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThis allele is a derivative of Blmtm2Brd. Three copies of a targeting vector that contained loxP sites inserted into the gene. Cre mediated recombination led to a deletion of the copies. This allele retains an extra copy of exon 3. However, western blot analysis on protein extracts of testes demonstrated that no detectable protein was produced from this allele. (J:66261)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Blmtm3Brd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Blm Mutation:  87 strains or lines available
References
Original:  J:66261 Luo G, et al., Cancer predisposition caused by elevated mitotic recombination in bloom mice. Nat Genet. 2000 Dec;26(4):424-9
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory