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Bmpr2tm1Kmi
Targeted Allele Detail
Nomenclature
Symbol: Bmpr2tm1Kmi
Name: bone morphogenetic protein receptor, type II (serine/threonine kinase); targeted mutation 1, Kohei Miyazono
MGI ID: MGI:2158503
Gene: Bmpr2  Location: Chr1:59763400-59879014 bp, + strand  Genetic Position: Chr1, 30.44 cM, cytoband C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61931
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exons 4 and 5. These sequences encode the transmembrane domain and the amino terminal region of the kinase domain. (J:61931)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmpr2 Mutation:  25 strains or lines available
References
Original:  J:61931 Beppu H, et al., BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol. 2000 May 1;221(1):249-58
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory