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Lmx1btm1Rjo
Targeted Allele Detail
Nomenclature
Symbol: Lmx1btm1Rjo
Name: LIM homeobox transcription factor 1 beta; targeted mutation 1, Randy L Johnson
MGI ID: MGI:2158463
Synonyms: Lmx1b-, Lmxbneo
Gene: Lmx1b  Location: Chr2:33560965-33640511 bp, - strand  Genetic Position: Chr2, 22.48 cM
Retarded development of the glomerular capillaries in Lmx1btm1Rjo/Lmx1btm1Rjo mice

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47316
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced about 5 kb of sequence including exons 3-7, which encode the second LIM domain, the homeodomain, and most of the carboxy-terminal region. RT-PCR analysis did not detect transcript from the region encoding the homeodomain in homozygous mutant 10 dpc embryos. (J:47316)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmx1b Mutation:  2 strains or lines available
References
Original:  J:47316 Chen H, et al., Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat Genet. 1998 May;19(1):51-5
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory