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Targeted Allele Detail
Symbol: Ptgs2tm1Unc
Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, University of North Carolina
MGI ID: MGI:2158457
Synonyms: Cox2-, COX-2-, PGHS-2-, Ptgs2tm1Smi
Gene: Ptgs2  Location: Chr1:150100031-150108227 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Hypertoprhy of glomeruli in Ptgs2tm1Unc/Ptgs2tm1Unc mice that is not seen in Ptgs2tm1.1Wls/Ptgs2tm1.1Wls mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:29510
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette was inserted into exon 8. A 104 bp DNA fragment containing sequences encoding essential residues tyrosine 371 and histidine 374 was also deleted. Northern blot analysis on mRNA derived from LPS-induced macrophages from homozygous mice demonstrated that an aberrant 6.0 kb transcript is produced from this allele. However, western blot analysis confirmed that no detectable protein is produced from this allele in LPS-induced macrophages derived from homozygous mice. (J:29510)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 30 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:  45 strains or lines available
BK4 is a subline of E14TG2a.
Original:  J:29510 Morham SG, et al., Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell. 1995 Nov 3;83(3):473-82
All:  136 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory