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Targeted Allele Detail
Symbol: Bcl6tm1Tto
Name: B cell leukemia/lymphoma 6; targeted mutation 1, Takeshi Tokuhisa
MGI ID: MGI:2158436
Synonyms: Bcl6-
Gene: Bcl6  Location: Chr16:23965052-23988852 bp, - strand  Genetic Position: Chr16, 15.26 cM
Germline Transmission:  Earliest citation of germline transmission: J:55952
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 4.0 kb genomic fragment spanning exons 3 - 6 was replaced with a neomycin selection cassette inserted in reverse transcriptional orientation to the gene. Northern blot analysis of mRNA derived from kidneys of homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:55952)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl6 Mutation:  29 strains or lines available
Original:  J:55952 Yoshida T, et al., The role of Bcl6 in mature cardiac myocytes. Cardiovasc Res. 1999 Jun;42(3):670-9
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory