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Targeted Allele Detail
Symbol: H2-Ab1tm1Gru
Name: histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Michael J Grusby
MGI ID: MGI:2158420
Synonyms: Ab1tm1Gru, Abb-, Abbeta-, Abbtm1, Abeta-, Abetab-, C2-, H2-Ab1-, H2-Ab1tm1Glm, I-Ab-, IAb-, IAbeta-, I-Abetab-, [KO]Abb, MHC class II-, MHC-II-deficient, mII-
Gene: H2-Ab1  Location: Chr17:34263209-34269418 bp, + strand  Genetic Position: Chr17, 17.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:74418
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 2. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins. (J:74418)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any H2-Ab1 Mutation:  34 strains or lines available
Phenotypic Similarity to Human Syndrome: Idiopathic Dilated Cardiomyopathy in double homozygous mice of the strain NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell (J:86540)

Original:  J:74418 Grusby MJ, et al., Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science. 1991 Sep 20;253(5026):1417-20
All:  268 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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