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Targeted Allele Detail
Symbol: Npr1tm1Mae
Name: natriuretic peptide receptor 1; targeted mutation 1, Nobuyo Maeda
MGI ID: MGI:2158387
Synonyms: Npr1-
Gene: Npr1  Location: Chr3:90450591-90465866 bp, - strand  Genetic Position: Chr3, 39.23 cM
Cardiac hypertrophy in Npr1tm1Mae/Npr1tm1Mae male mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:74420
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exon 1 and part of intron 1 was replaced with a neomycin selection cassette. The deleted sequences encode 237 amino acids from the N-terminal region of the corresponding protein. Western blot analysis on kidney membranes derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:74420)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npr1 Mutation:  25 strains or lines available
Original:  J:74420 Oliver PM, et al., Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14730-5
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory