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Targeted Allele Detail
Symbol: Npr3tm1Unc
Name: natriuretic peptide receptor 3; targeted mutation 1, University of North Carolina
MGI ID: MGI:2158355
Synonyms: Npr3tm1Smi
Gene: Npr3  Location: Chr15:11839896-11905674 bp, - strand  Genetic Position: Chr15, 5.83 cM
Skeletal phenotypes of Npr3tm1Unc/Npr3tm1Unc mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:56058
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing sequences encoding 215 amino acids of the ligand binding domain was replaced with a neomycin selection gene. Photoaffinity labeling analysis revealed that no functional protein was made in lung plasma membranes in homozygous mice. (J:56058)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npr3 Mutation:  24 strains or lines available
Original:  J:56058 Matsukawa N, et al., The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7403-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory