Ccr2^tm1Mae
Targeted Allele Detail

Summary

• Symbol: Ccr2^tm1Mae
• Name: C-C motif chemokine receptor 2; targeted mutation 1, Nobuyo Maeda
• MGI ID: MGI:2158345
• Synonyms: CCR2-, Ccr2^tm1Unc
• Gene: Ccr2 Location: Chr9:123901987-123913594 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr2^tm1Mae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44561
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted in reverse transcriptional orientation in front of the coding sequence for the first transmembrane domain of the encoded protein. Competitive binding assays demonstrated a reduction in specific binding of labeled ligand to peritoneal exudate cells derived from homozygous mice. (J:44561)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ccr2 Mutation: 40 strains or lines available

References

• Original: J:44561 Kuziel WA, et al., Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12053-8
• All: 154 reference(s)