Bmpr1a^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Bmpr1a^tm1Bhr
• Name: bone morphogenetic protein receptor, type 1A; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:2158342
• Synonyms: Alk3^null, Bmpr1a^-, Bmpr-s
• Gene: Bmpr1a Location: Chr14:34133018-34225335 bp, - strand Genetic Position: Chr14, 20.81 cM
• Alliance: Bmpr1a^tm1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30426
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin resistance cassette replaced 6.2 kb of sequence including the first two exons, which encode the translation initiation codon, the signal peptide, and ~30% of the extracellular domain. (J:30426)

Disease models

Expression

In Mice Carrying this Mutation:	49 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmpr1a Mutation: 89 strains or lines available

References

• Original: J:30426 Mishina Y, et al., Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev. 1995 Dec 15;9(24):3027-37
• All: 44 reference(s)