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Targeted Allele Detail
Symbol: Bcl10tm1Mak
Name: B cell leukemia/lymphoma 10; targeted mutation 1, Tak W Mak
MGI ID: MGI:2158304
Synonyms: Bcl10-
Gene: Bcl10  Location: Chr3:145924262-145934366 bp, + strand  Genetic Position: Chr3, 71.03 cM, cytoband H3
Germline Transmission:  Earliest citation of germline transmission: J:67297
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exon 2 and all of the coding sequence of exon 3 was replaced with a neomycin selection cassette inserted in reverse trancriptional orientation to the gene. Western blot analysis on embryonic fibroblast lysates derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:67297)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl10 Mutation:  2 strains or lines available
Original:  J:67297 Ruland J, et al., Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell. 2001 Jan 12;104(1):33-42
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory