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Cd2tm1Litt
Targeted Allele Detail
Nomenclature
Symbol: Cd2tm1Litt
Name: CD2 antigen; targeted mutation 1, Dan R Littman
MGI ID: MGI:2158301
Synonyms: CD2-, Cd2tm1Drl
Gene: Cd2  Location: Chr3:101275908-101287939 bp, - strand  Genetic Position: Chr3, 44.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:3149
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 2, into sequences encoding the amino terminal V-like domain. Northern blot analysis demonstrated that no stable transcript was produced from this allele. Immunocytochemistry analysis demonstrated that no functional protein was present on the surface of lymphocytes. (J:3149)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd2 Mutation:  16 strains or lines available
References
Original:  J:3149 Killeen N, et al., Development and function of T cells in mice with a disrupted CD2 gene. EMBO J. 1992 Dec;11(12):4329-36
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory