Cd2^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Cd2^tm1Litt
• Name: CD2 antigen; targeted mutation 1, Dan R Littman
• MGI ID: MGI:2158301
• Synonyms: CD2-, Cd2^tm1Drl
• Gene: Cd2 Location: Chr3:101183224-101195255 bp, - strand Genetic Position: Chr3, 44.17 cM
• Alliance: Cd2^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3149
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 2, into sequences encoding the amino terminal V-like domain. Northern blot analysis demonstrated that no stable transcript was produced from this allele. Immunocytochemistry analysis demonstrated that no functional protein was present on the surface of lymphocytes. (J:3149)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd2 Mutation: 19 strains or lines available

References

• Original: J:3149 Killeen N, et al., Development and function of T cells in mice with a disrupted CD2 gene. EMBO J. 1992 Dec;11(12):4329-36
• All: 10 reference(s)