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Targeted Allele Detail
Symbol: Atp4btm1Ird
Name: ATPase, H+/K+ exchanging, beta polypeptide; targeted mutation 1, Ian R van Driel
MGI ID: MGI:2158258
Synonyms: Atp4bkls, Atp4bo, H/Kbeta, HKbeta-
Gene: Atp4b  Location: Chr8:13386205-13396825 bp, - strand  Genetic Position: Chr8, 5.89 cM
Germline Transmission:  Earliest citation of germline transmission: J:74022
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection casssette replaced 35 bp of exon 1. RT-PCR analysis demonstrated that no stable transcript was present in gastric tissue of homozygous mice, and western blot analysis showed that no stable protein was produced from this allele in gastric membranes derived from homozygous mice. (J:74022)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp4b Mutation:  16 strains or lines available
Original:  J:74022 Scarff KL, et al., Gastric H(+),K(+)-adenosine triphosphatase beta subunit is required for normal function, development, and membrane structure of mouse parietal cells. Gastroenterology. 1999 Sep;117(3):605-18
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory