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Atp4atm1Ges
Targeted Allele Detail
Nomenclature
Symbol: Atp4atm1Ges
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide; targeted mutation 1, Gary E Shull
MGI ID: MGI:2158246
Synonyms: H/Kalpha-
Gene: Atp4a  Location: Chr7:30712209-30725534 bp, + strand  Genetic Position: Chr7, 19.2 cM
Disruption of the gastric mucosa architecture in Atp4atm1Ges/Atp4atm1Ges mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63470
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA part of exon 8 encoding amino acids 360-390 was replaced with a neomycin selection cassette. Northern blot analysis demonstrated that no detectable full length transcript was produced from this allele in stomach of homozygous mice, although trace levels of a shorter 1 kb transcript was detected. Immunocytochemistry experiments on stomach tissue of homozygous mice demonstrated that no detectable protein was present. (J:63470)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp4a Mutation:  32 strains or lines available
References
Original:  J:63470 Spicer Z, et al., Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. J Biol Chem. 2000 Jul 14;275(28):21555-65
All:  14 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory