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Targeted Allele Detail
Symbol: Atp2a2tm1Ges
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; targeted mutation 1, Gary E Shull
MGI ID: MGI:2158235
Synonyms: SERCA2a-, SERCA2a knockout
Gene: Atp2a2  Location: Chr5:122453513-122502225 bp, - strand  Genetic Position: Chr5, 62.38 cM, cytoband F
Squamous cell carcinomas and papillomas of keratinized epithelial tissues in Atp2a2tm1Ges/Atp2a2+ mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:52186
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing the promoter, transcription initiation site, the first two exons and part of the third exon was replaced with a neomycin selection cassette. (J:52186)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp2a2 Mutation:  33 strains or lines available
Original:  J:52186 Periasamy M, et al., Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. J Biol Chem. 1999 Jan 22;274(4):2556-62
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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