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Mop2C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Mop2C57BL/6J
Name: morphine preference 2; C57BL/6J
MGI ID: MGI:2158228
QTL: Mop2  Location: Chr10:9413375-29152428 bp  Genetic Position: Chr10, cM position of peak correlated region/allele: 3.04 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased morphine preference compared to DBA/2J. (J:17972)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
This allele is consistent with a dominant or additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:17972

Morphine consumption was assessed in 606 F2 mice from a C57BL/6J x DBA/2J intercross. A subset of the 606 progeny were tested for QTL (quantitative trait analysis).

An increase in the preference for morphine consumption, Mop2, was mapped between flanking microsatellite markers D10Mit28 and D10Mit3 on Chromosome 10 with a lod score of 20.0.

References
Original:  J:17972 Berrettini WH, et al., Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains [see comments]. Nat Genet. 1994 May;7(1):54-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory