Lmb4^MRL/MpScr
QTL Variant Detail

Summary

• QTL variant: Lmb4^MRL/MpScr
• Name: lupus in MRL and B6 F2 cross, QTL 4; MRL/MpScr
• MGI ID: MGI:2158218
• QTL: Lmb4 Location: Chr10:66848187-92258673 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 34.29 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MRL-Fas^lpr

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to splenomegaly and lymphadenopathy compared to C57BL/6. (J:45708)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

This allele is consistent with a recessive or additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:45708

In a (MRL-Tnfrsf6^lpr x C57BL/6-Tnfrsf6^lpr)F1 cross involving 274 F2 progeny a quantitative trait locus, Lmb4, identifying lymphadenopathy and/or splenomegaly was significantly associated with a region of mouse Chromosome 10 flanked by markers D10Mit20 and D10Mit11. The highest LOD scores were associated with D10Mit11.

References

• Original: J:45708 Vidal S, et al., Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice. J Clin Invest. 1998 Feb 1;101(3):696-702
• All: 2 reference(s)