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QTL Variant Detail
QTL variant: Estq4C57BL/6J
Name: estradiol regulated response QTL 4; C57BL/6J
MGI ID: MGI:2158118
QTL: Estq4  Location: Chr10:118150611-118150744 bp  Genetic Position: Chr10, cM position of peak correlated region/allele: 66.65 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased leukocyte infiltration in the presence of C57BL/6J alleles at Estq1. (J:53494)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Estq4 participates in interactions with Estq1 and Estq3.

Mapping and Phenotype information for this QTL, its variants and associated markers


To understand the overall genetic control of estradiol regulated uterine response, the authors performed multiple trait analysis for both QTLs contributing to uterine weight and infiltrating eosinophils. Linkage was found to marker loci D4Mit6 (Estq1; LRT = 15.05), D5Mit296 (Estq2; LRT = 17.84), D10Mit180 (LRT = 16.02) and D11Mit67 (Estq3; LRT = 14.38; [a] = 0.10 and [a] = 0.05 thresholds equal 14.60 and 6.72, respectively). Based on the significance of D10Mit180 eosinophil infiltration, significant interaction of D10Mit180 in estradiol regulated responses, and the significance of the locus in mutilpe trait analysis, the QTL linked to D10Mit180 has been designated as Estq4.

Original:  J:52898 Roper RJ, et al., Interacting quantitative trait loci control phenotypic variation in murine estradiol-regulated responses. Endocrinology. 1999 Feb;140(2):556-61
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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