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Ptger3tm1Cof
Targeted Allele Detail
Nomenclature
Symbol: Ptger3tm1Cof
Name: prostaglandin E receptor 3 (subtype EP3); targeted mutation 1, Thomas M Coffman
MGI ID: MGI:2157796
Synonyms: EP3-
Gene: Ptger3  Location: Chr3:157566819-157644758 bp, + strand  Genetic Position: Chr3, 81.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52323
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neo cassette is inserted into exon 1. Exon 1 contains the the 5' untranslated sequence and a large portion of the coding region that extends through the sixth transmembrane domain. Northern analysis in RNA prepared from kidneys failed to detect a trasncript. (J:52323)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptger3 Mutation:  8 strains or lines available
References
Original:  J:52323 Fleming EF, et al., Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2. Am J Physiol. 1998 Dec;275(6 Pt 2):F955-61
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory