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Targeted Allele Detail
Symbol: Il1btm1Lvp
Name: interleukin 1 beta; targeted mutation 1, Lex H T Van der Ploeg
MGI ID: MGI:2157795
Synonyms: IL-1beta-, IL-1beta-
Gene: Il1b  Location: Chr2:129364570-129371139 bp, - strand  Genetic Position: Chr2, 62.97 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:27234
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced the first six exons. Northern blot analysis of liver tissue taken three hours after LPS injection did not detect mRNA in sensitized homozygous mutant mice. (J:27234)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il1b Mutation:  12 strains or lines available
Original:  J:27234 Zheng H, et al., Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice. Immunity. 1995 Jul;3(1):9-19
All:  36 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory