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Il1btm1Lvp
Targeted Allele Detail
Nomenclature
Symbol: Il1btm1Lvp
Name: interleukin 1 beta; targeted mutation 1, Lex H T Van der Ploeg
MGI ID: MGI:2157795
Synonyms: IL-1beta-, IL-1beta-
Gene: Il1b  Location: Chr2:129364570-129371139 bp, - strand  Genetic Position: Chr2, 62.97 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:27234
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced the first six exons. Northern blot analysis of liver tissue taken three hours after LPS injection did not detect mRNA in sensitized homozygous mutant mice. (J:27234)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il1b Mutation:  2 strains or lines available
References
Original:  J:27234 Zheng H, et al., Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice. Immunity. 1995 Jul;3(1):9-19
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory