Il1b^tm1Lvp
Targeted Allele Detail

Summary

• Symbol: Il1b^tm1Lvp
• Name: interleukin 1 beta; targeted mutation 1, Lex H T Van der Ploeg
• MGI ID: MGI:2157795
• Synonyms: IL-1beta^-, IL-1beta-
• Gene: Il1b Location: Chr2:129206490-129213059 bp, - strand Genetic Position: Chr2, 62.97 cM, cytoband F
• Alliance: Il1b^tm1Lvp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27234
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the first six exons. Northern blot analysis of liver tissue taken three hours after LPS injection did not detect mRNA in sensitized homozygous mutant mice. (J:27234)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1b Mutation: 24 strains or lines available

References

• Original: J:27234 Zheng H, et al., Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice. Immunity. 1995 Jul;3(1):9-19
• All: 39 reference(s)