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TlfNOD/Smrf
QTL Variant Detail
Summary
QTL variant: TlfNOD/Smrf
Name: T lymphocyte fraction; NOD/Smrf
MGI ID: MGI:2157567
QTL: Tlf  Location: Chr9:34837748-37306370 bp  Genetic Position: Chr9, cM position of peak correlated region/allele: 52.24 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  NOD/Smrf
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased CD4+ levels in male animals compared to NOD/Lt. (J:49676)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:30526

The percentage of circulating CD4+ T Cells in NOD/Smrf mice is 40-50% greater then NON/Lt mice, enabling the investigation of how this quantitative phenotype segregates in a BC1 population (NON/Lt x NOD/Smrf)F1 x NOD/Smrf and in an F2 population (NON/Lt x NOD/Smrf)F1 x (NON/Lt x NOD/Smrf)F1. Statistical analysis using t-tests showed a significant correlation of circulating CD4+ T cells with the mouse Chromosome 9 marker D9Mit12 in both male and female segregants. The gene or genetic region responsible for this phenotype is termed Tlf (T lymphocyte frequency) Importantly, the authors show a correlation of Tlf with diabetic incidence as expressed by NON/Lt and NOD/Smrf mice suggesting that Tlf may in fact be the mouse Chromosome 9 locus Idd2.

J:49676

The author refines the mapping of a region which governs the unusually high fraction of circulating T lymphocytes in the nonobese diabetic (NOD) mice. Linkage analysis of (NON/Lt x NOD/Smrf)F1 x NOD/Smrf, and (NOD/Smrf x NON/Lt)F1 x NOD/Smrf progeny, and F2 animals from F1 crosses indicates that the phenotype is associated with two regions of mouse Chromosme 9. One region, Tlf, was placed between D9Mit66 (15 cM) and D9Mit2 (17 cM). The second region, Tlf2, was placed distal near D9Mit71 (29 cM).

References
Original:  J:49676 Pearce RB, Fine-mapping of the mouse T lymphocyte fraction (Tlf) locus on chromosome 9: association with autoimmune diabetes. Autoimmunity. 1998;28(1):31-45
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory