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Nr4a2tm1Tpe
Targeted Allele Detail
Nomenclature
Symbol: Nr4a2tm1Tpe
Name: nuclear receptor subfamily 4, group A, member 2; targeted mutation 1, Thomas Perlmann
MGI ID: MGI:2157566
Synonyms: Nurr1-
Gene: Nr4a2  Location: Chr2:57106830-57124003 bp, - strand  Genetic Position: Chr2, 31.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39661
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a neomycin resistance cassette replaces the sequence encoding the N terminal transactivation and DNA binding domains (exons 2,3 and part of 4). In situ hybridization detected no transcript from this gene in homozygous mutant mice. (J:39661)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr4a2 Mutation:  22 strains or lines available
References
Original:  J:39661 Zetterstrom RH, et al., Dopamine neuron agenesis in Nurr1-deficient mice [see comments]. Science. 1997 Apr 11;276(5310):248-50
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory