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QTL Variant Detail
QTL variant: Apmt1FVB/NJ
Name: accelerator of polyoma-induced mammary tumors 1; FVB/NJ
MGI ID: MGI:2157320
QTL: Apmt1  Location: unknown  Genetic Position: Chr15, cM position of peak correlated region/allele: 22.82 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  FVB/NJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased mammary tumor susceptibility compared to I/LnJ. (J:64663)
Inheritance:    Other (see notes)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Apmt1 exhibits additive inheritance and interacts epistatically with Apmt2. Animals homozygous for FVB/NJ-derived alleles at Apmt1 and heterozygous at Apmt2 exhibit the highest incidence of mammary tumors.

Mapping and Phenotype information for this QTL, its variants and associated markers


A genome wide scan using 69 markers was initiated to find loci responsible for tumor acceleration in mice. A total of 126 female mice from FVB/N females X (I/LnJ females X FVB/N-TgN(MMTVPyVT)634mul males) F1 males were informative. A region of mouse Chromosome 15 was associated with an acceleration of tumorignensis in I/LnJ mice with a peak LOD score (3.3) near D15Mit184.

Original:  J:64663 Le Voyer T, et al., An epistatic interaction controls the latency of a transgene-induced mammary tumor. Mamm Genome. 2000 Oct;11(10):883-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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