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Targeted Allele Detail
Symbol: Apobec1tm1Ddsn
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; targeted mutation 1, Nicholas O Davidson
MGI ID: MGI:2157186
Synonyms: apoB100-, apobec-1-, apobec-1 KO
Gene: Apobec1  Location: Chr6:122577792-122602444 bp, - strand  Genetic Position: Chr6, 57.68 cM
Germline Transmission:  Earliest citation of germline transmission: J:32731
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exon 6, encoding the zinc finger and catalytic glutamate, was replaced with a neomycin selection cassette. No transcript was detectable in RNAse protection assays on RNA isolated from liver and small intestine of homozygous mice. (J:32731)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apobec1 Mutation:  18 strains or lines available
Original:  J:32731 Hirano K, et al., Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem. 1996 Apr 26;271(17):9887-90
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory