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Targeted Allele Detail
Symbol: Apoa2tm1Bres
Name: apolipoprotein A-II; targeted mutation 1, Jan L Breslow
MGI ID: MGI:2157148
Synonyms: apoA-II -
Gene: Apoa2  Location: Chr1:171225054-171226379 bp, + strand  Genetic Position: Chr1, 79.22 cM
Germline Transmission:  Earliest citation of germline transmission: J:37250
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exons 1-3 and part of exon 4 was replaced with a neomycin selection cassette. Northern blot analysis on total liver RNA demonstrated that the transcript was not detectable in homozygous mice, and the encoded protein was not detected in HDL isolates of plasma derived from homozygous mice. (J:37250)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apoa2 Mutation:  7 strains or lines available
Original:  J:37250 Weng W, et al., Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14788-94
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory