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QTL Variant Detail
QTL variant: Cafq3C3H/HeJ
Name: caffeine metabolism QTL 3; C3H/HeJ
MGI ID: MGI:2157128
QTL: Cafq3  Location: unknown  Genetic Position: Chr9, cM position of peak correlated region/allele: 31.71 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL
Inheritance:    Not Specified
Cafq3 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers


QTL mapping was performed on 438 F2 animals from an intercross between the acetaminophen nonsusceptible (APN) strain and C3H/HeJ to identify loci associated with caffeine metabolism. The average spacing between markers is 13 cM. Caffeine metabolism QTLs mapped to mouse Chromosome 1 (Cafq1), mouse Chromosome 4 (Cafq2), and mouse Chromosome 9 (Cafq3). Cafq1 is located 85 cM - 95.8 cM on mouse Chromosome 1 with a peak LOD = 9.7 at D1Mit356. No obvious candidate genes are found near Cafq1. Males show a stronger association to the phenotype than females at this locus. Cafq2 is located 31.4 cM - 57 cM on mouse Chromosome 4 with a peak LOD = 3.4 at D4Mit199. Cafq3 is located 28 cM - 48 cM on mouse Chromosome 9 with a peak LOD = 25 at D9Mit248 and D9Mit21. Cyp1a2 is a likely positional candidate gene for Cafq3 based on its known role in caffeine metabolism and differences in protein and mRNA expression of Cyp1a2 between the parental strains.

Original:  J:68139 Casley WL, et al., Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice. Drug Metab Dispos. 1999 Dec;27(12):1375-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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