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Cafq3C3H/HeJ
QTL Variant Detail
Nomenclature
QTL variant: Cafq3C3H/HeJ
Name: caffeine metabolism QTL 3; C3H/HeJ
MGI ID: MGI:2157128
QTL: Cafq3  Location: unknown  Genetic Position: Chr9, cM position of peak correlated region/allele: 31.71 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C3H/HeJ
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes
Cafq3 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68139

QTL mapping was performed on 438 F2 animals from an intercross between the acetaminophen nonsusceptible (APN) strain and C3H/HeJ to identify loci associated with caffeine metabolism. The average spacing between markers is 13 cM. Caffeine metabolism QTLs mapped to mouse Chromosome 1 (Cafq1), mouse Chromosome 4 (Cafq2), and mouse Chromosome 9 (Cafq3). Cafq1 is located 85 cM - 95.8 cM on mouse Chromosome 1 with a peak LOD = 9.7 at D1Mit356. No obvious candidate genes are found near Cafq1. Males show a stronger association to the phenotype than females at this locus. Cafq2 is located 31.4 cM - 57 cM on mouse Chromosome 4 with a peak LOD = 3.4 at D4Mit199. Cafq3 is located 28 cM - 48 cM on mouse Chromosome 9 with a peak LOD = 25 at D9Mit248 and D9Mit21. Cyp1a2 is a likely positional candidate gene for Cafq3 based on its known role in caffeine metabolism and differences in protein and mRNA expression of Cyp1a2 between the parental strains.

References
Original:  J:68139 Casley WL, et al., Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice. Drug Metab Dispos. 1999 Dec;27(12):1375-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory