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QTL Variant Detail
QTL variant: Taste10C3H/HeJ
Name: taste bitterness sensitivity 10; C3H/HeJ
MGI ID: MGI:2157055
QTL: Taste10  Location: unknown  Genetic Position: Chr8, Syntenic
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


12 BXH/Ty RI (recombinant inbred) strains were typed at 212 loci at an average spacing of 7 cM to identify QTLs involved in bitterness avoidance. C57BL/6J (B) parental strain exhibits strong bitterness aversion to quinine sulfate and PROP (6-n-propyl-thiouracil) while C3H/HeJ (C) parental strain is indifferent. 6 bitterness sensitivity loci (Taste7-Taste12) achieving a threshold of P<0.01 mapped to 4 different mouse Chromosomes. Taste7 maps to 72 cM on mouse chromosome 3 near Mpmv9. Taste8 maps to 49.5 cM on mouse chromosome 6 near Ea10. Taste9 also maps to chromosome 6 at 63 cM near Prp and shows the strongest association to bitterness sensitivity. A cluster of bitterness-aversion loci, Cyx (50 cM), Qui (50.5 cM) and Rua (51 cM) are found near Taste9. Taste10 maps to 32 cM on mouse Chromosome 8 near Cpe. Taste11 and Taste12 map to mouse Chromosome 9 at 42 cM near D9Mit8 and 48 cM near D9Mit9, respectively.

Original:  J:48606 Harder DB, et al., A common polygenic basis for quinine and PROP avoidance in mice. Chem Senses. 1998 Jun;23(3):327-32
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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