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Targeted Allele Detail
Symbol: Cfdtm1Yxu
Name: complement factor D (adipsin); targeted mutation 1, Yuanyuan Xu
MGI ID: MGI:2156994
Synonyms: Df-, factor D-, fD-, fD KO
Gene: Cfd  Location: Chr10:79890853-79892655 bp, + strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:73125
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin resistance cassette into exon 3, which encodes the Asp residue of the serine protease active center, disrupted the gene. Northern blot analyses of fat, muscle, lung, and liver did not detect message in homozygous mutant mice. Western blot analysis did not detect protein in homozygous mutant mouse sera. (J:73125)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cfd Mutation:  8 strains or lines available
Original:  J:73125 Xu Y, et al., Complement activation in factor D-deficient mice. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14577-82
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory