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Targeted Allele Detail
Symbol: Ppp3r1tm1Stl
Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); targeted mutation 1, Susumu Tonegawa
MGI ID: MGI:2156983
Synonyms: fCNB1, PP2B-loxP
Gene: Ppp3r1  Location: Chr11:17159263-17200375 bp, + strand  Genetic Position: Chr11, 9.71 cM, cytoband A3.1
Germline Transmission:  Earliest citation of germline transmission: J:73203
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsHomologous recombination flanked the three major coding exons, exons 2-4, with a loxP site and a LFNT cassette. The LFNT cassette consisted of PGK-neomycin and HSV-thymidine kinase selection sequences flanked by a pair of loxP sites and a pair of frt sites. Cre- or Flp-mediated recombination in ES cells removed the PGK-neomycin and HSV-thymidine kinase sequences prior to production of chimeras. (J:73203)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppp3r1 Mutation:  27 strains or lines available
Original:  J:73203 Zeng H, et al., Forebrain-Specific Calcineurin Knockout Selectively Impairs Bidirectional Synaptic Plasticity and Working/Episodic-like Memory. Cell. 2001 Nov 30;107(5):617-29
All:  12 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory