Cons2^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Cons2^DBA/2J
• Name: consumption-saccharin intake 2; DBA/2J
• MGI ID: MGI:2156803
• QTL: Cons2 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 48.43 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50271

841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta7 (P<0.01 at D7Ncvs57) mapped to chromosome 7 at 36 cM. Etohcta7 is associated with ethanol-induced taste aversion at low-dose ethanol injection following the paired taste. Cons2 (P<0.01 at D7Mit234a) mapped to Chromosome 7 at 44 cM and is associated with preconditioned saccharin intake.

References

• Original: J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• All: 1 reference(s)