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TabwCAST/EiJ
QTL Variant Detail
Summary
QTL variant: TabwCAST/EiJ
Name: TallyHo associated body weight; CAST/EiJ
MGI ID: MGI:2156675
QTL: Tabw  Location: Chr7:66193278-66193390 bp  Genetic Position: Chr7, cM position of peak correlated region/allele: 35.91 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  CAST/EiJ
Variant
description
Allele Type:    QTL
Inheritance:    Dominant
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:70227

Linkage analysis was performed on (C57BL/6J x TH)F1 x TH male backcross animals and (CAST/Ei x TH)F1 x TH male backcross animals to identify QTLs associated with diabetes-related phenotypes. The TH (TallyHo) strain is a mouse model for human non-insulin dependent diabetes mellitus (NIDDM). TH males develop hyperglycemia by 10-14 weeks of age whereas C57BL/6J and CAST/Ei males are normoglycemic. TH animals also exhibit increased body weight and fat pad weights compared to non-diabetic C57BL/6J and CAST/Eistrains. A locus associated with NIDDM, Tanidd1 (TallyHo associated NIDDM 1), mapped to mouse Chromosome 19 from 16 cM - 60 cM in both backcross sets (LOD = 3.1 at D19Mit103). Tanidd2 mapped to mouse Chromosome 13 from 5 cM - 70 cM in the C57BL6/J backcross (LOD = 4 at D13Mit148) and Tanidd3 mapped to mouse Chromosome 16 from 0 cM - 34 cM in the CAST/Ei backcross (LOD = 2.8 at D16Mit129). TH-derived alleles confer recessively inherited hyperglycemia at Tanidd1, Tanidd2, and Tanidd3. A QTL associated withbody weight, Tabw (TallyHo associated body weight), mapped to mouse Chromosome 7 from 0 cM - 44 cM (LOD = 3.9 at D7Mit231), and a QTL associated with fat pad weight, Tafat (TallyHo associated fat pad), mapped to mouse Chromosome 4 from 68 cM - 90 cM (LOD= 3.1 at D4Mit312). Animals homozygous for TH-derived alleles at Tafat exhibit lower fat pad weights than heterozygous animals, and animals homozygous for TH-derived alleles at Tabw exhibit lower body weights than heterozygous animals. The insulin gene, Ins1, maps near Tanidd1 and was considered as a candidate gene but sequence analysis failed to reveal differences between TH and C57BL/6J in the Ins1 promoter and coding regions.

References
Original:  J:70227 Kim JH, et al., Genetic analysis of a new mouse model for non-insulin-dependent diabetes. Genomics. 2001 Jun 15;74(3):273-86
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory