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Ots1LT/Sv
QTL Variant Detail
Nomenclature
QTL variant: Ots1LT/Sv
Name: ovarian teratoma susceptibility 1; LT/Sv
MGI ID: MGI:2156627
QTL: Ots1  Location: Chr6:75424566-104480516 bp  Genetic Position: Chr6, cM position of peak correlated region/allele: 44.78 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  LT/Sv
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers ovarian tumor susceptibility compared to C57BL/6J. (J:38481)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:38481

The inbred mouse strain LT/Sv expresses a high incidence of spontaneous ovarian tumors. A genome wide scan using markers that were polymorphic between LT/Sv and C57BL/6J were informative in quantitatively mapping the tumor susceptible phenotype in (LT/Svx C57BL/6J)F2 mice to a region of mouse Chromosome 6. The maximum LOD score (8.4) defining this region is flanked by markers D6Mit188 and D6Mit36.

References
Original:  J:38481 Lee GH, et al., Genetic dissection of susceptibility to murine ovarian teratomas that originate from parthenogenetic oocytes. Cancer Res. 1997 Feb 15;57(4):590-3
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory