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Wrntm1Led
Targeted Allele Detail
Nomenclature
Symbol: Wrntm1Led
Name: Werner syndrome homolog (human); targeted mutation 1, Philip Leder
MGI ID: MGI:2156622
Synonyms: Wrndeltahel, WS
Gene: Wrn  Location: Chr8:33234384-33385527 bp, - strand  Genetic Position: Chr8, 20.3 cM, cytoband A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48424
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wrn Mutation:  8 strains or lines available
References
Original:  J:48424 Lebel M, et al., A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13097-102
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory