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Targeted Allele Detail
Symbol: Wrntm1Led
Name: Werner syndrome RecQ like helicase; targeted mutation 1, Philip Leder
MGI ID: MGI:2156622
Synonyms: Wrndeltahel, WS
Gene: Wrn  Location: Chr8:33724412-33875555 bp, - strand  Genetic Position: Chr8, 20.3 cM, cytoband A4
Germline Transmission:  Earliest citation of germline transmission: J:48424
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 and 4 were replaced with a neomycin selection cassette. The targeted allele is expected to express a fully translated protein that lacks 121 amino acids of the helicase domain. (J:48424)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wrn Mutation:  54 strains or lines available
Original:  J:48424 Lebel M, et al., A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13097-102
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory