Dsp^tm1Efu
Targeted Allele Detail

Summary

• Symbol: Dsp^tm1Efu
• Name: desmoplakin; targeted mutation 1, Elaine Fuchs
• MGI ID: MGI:2156542
• Gene: Dsp Location: Chr13:38335270-38382553 bp, + strand Genetic Position: Chr13, 18.0 cM
• Alliance: Dsp^tm1Efu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73084
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin and thymidine kinase expression cassette were inserted 3' to exon 2, and a single loxP site was inserted 5' of exon 2. Cre-mediated recombination in ES cells removed the neo and tk sequences, leaving a single loxP site 3' to exon 2. (J:73084)

Disease models

Expression

In Mice Carrying this Mutation:	71 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dsp^tm1Efu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dsp Mutation: 136 strains or lines available

Notes

ES cell line = GS1 (129/Sv) or RW-4 (129X1/SvJ).

References

• Original: J:73084 Vasioukhin V, et al., Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol. 2001 Dec;3(12):1076-85
• All: 23 reference(s)