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Targeted Allele Detail
Symbol: Agtr1atm1Afu
Name: angiotensin II receptor, type 1a; targeted mutation 1, Akiyoshi Fukamizu
MGI ID: MGI:2156487
Synonyms: AT1-, AT1a-, AT1A-KO, AT1aR-, AT1KO, AT1-R KO, ATKO, mAT1a-
Gene: Agtr1a  Location: Chr13:30520424-30566850 bp, + strand  Genetic Position: Chr13, 13.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:28041
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA promoterless lacZ gene followed by a neomycin selection cassette replaced the entire coding sequence of the gene. Northern blot analysis demonstrated that no wild-type transcript was produced from this allele. Immunohistochemical analysis indicated that beta-galactosidase was expressed from this allele in the renal cortex of homozygous mice. (J:28041)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agtr1a Mutation:  29 strains or lines available
Original:  J:28041 Sugaya T, et al., Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J Biol Chem. 1995 Aug 11;270(32):18719-22
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory