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Targeted Allele Detail
Symbol: Mbtps1tm1.1Jdh
Name: membrane-bound transcription factor peptidase, site 1; targeted mutation 1.1, Jay D Horton
MGI ID: MGI:2156485
Synonyms: S1P-
Gene: Mbtps1  Location: Chr8:119508156-119558761 bp, - strand  Genetic Position: Chr8, 67.85 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:72930
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele is a derivative of Mbtps1tm1Jdh. Mice carrying the Mbtps1tm1Jdh allele were mated to mice carrying a transgene expressing Cre recombinase in the male germline. Progeny of this cross were screened for deletion of exon 2, the neomycin selection cassette and flanking intronic sequences in all tissues. (J:72930)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mbtps1 Mutation:  45 strains or lines available
Original:  J:72930 Yang J, et al., Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13607-12
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory