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Targeted Allele Detail
Symbol: Epha4tm1Byd
Name: Eph receptor A4; targeted mutation 1, Andrew W Boyd
MGI ID: MGI:2156472
Synonyms: Epha4-, Epha4KO
Gene: Epha4  Location: Chr1:77367185-77515088 bp, - strand  Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
Disruption of spinal cord architecture and the anterior commissure in Epha4tm1Byd/Epha4tm1Byd mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:50573
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced exon 3, corresponding to nucleotides 217-880 of the encoded transcript. Immunohistochemical analysis on E8.5 embryos demonstrated that the encoded protein was not detectable in rhomdomeres of homozygous mice. (J:50573)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epha4 Mutation:  9 strains or lines available
Original:  J:50573 Dottori M, et al., EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13248-53
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory