Cdc42^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Cdc42^tm1Fwa
• Name: cell division cycle 42; targeted mutation 1, Fredrick W Alt
• MGI ID: MGI:2156460
• Gene: Cdc42 Location: Chr4:137047007-137085031 bp, - strand Genetic Position: Chr4, 69.83 cM
• Alliance: Cdc42^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63261
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A loxP flanked neomycin selection cassette replaced the first coding exon of the gene. (J:63261)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc42 Mutation: 43 strains or lines available

References

• Original: J:63261 Chen F, et al., Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol. 2000 Jun 29;10(13):758-65
• All: 2 reference(s)